CCL2-driven inflammation increases mammary gland stromal density and cancer susceptibility in a transgenic mouse model
Abstract
Macrophages play diverse roles in mammary gland development and breast cancer. CC-chemokine ligand 2 (CCL2) is an inflammatory cytokine that recruits macrophages to sites of injury. Although CCL2 has been detected in human and mouse mammary epithelium, its role in regulating mammary gland development and cancer risk has not been explored. Transgenic mice were generated wherein CCL2 is driven by the mammary epithelial cell-specific mouse mammary...
Paper Details
Title
CCL2-driven inflammation increases mammary gland stromal density and cancer susceptibility in a transgenic mouse model
Published Date
Jan 11, 2017
Journal
Volume
19
Issue
1
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