Challenges in Infective Endocarditis.

Published on Jan 24, 2017in Journal of the American College of Cardiology20.589
· DOI :10.1016/J.JACC.2016.10.066
Thomas J. Cahill5
Estimated H-index: 5
(University of Oxford),
Larry M. Baddour90
Estimated H-index: 90
(Mayo Clinic)
+ 5 AuthorsBernard Prendergast60
Estimated H-index: 60
(St Thomas' Hospital)
Sources
Abstract
Abstract Infective endocarditis is defined by a focus of infection within the heart and is a feared disease across the field of cardiology. It is frequently acquired in the health care setting, and more than one-half of cases now occur in patients without known heart disease. Despite optimal care, mortality approaches 30% at 1 year. The challenges posed by infective endocarditis are significant. It is heterogeneous in etiology, clinical manifestations, and course. Staphylococcus aureus , which has become the predominant causative organism in the developed world, leads to an aggressive form of the disease, often in vulnerable or elderly patient populations. There is a lack of research infrastructure and funding, with few randomized controlled trials to guide practice. Longstanding controversies such as the timing of surgery or the role of antibiotic prophylaxis have not been resolved. The present article reviews the challenges posed by infective endocarditis and outlines current and future strategies to limit its impact.
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