RNA Binding to CBP Stimulates Histone Acetylation and Transcription.

Cell64.50
Volume: 168, Issue: 1, Pages: 135 - 149
Published: Jan 12, 2017
Abstract
CBP/p300 are transcription co-activators whose binding is a signature of enhancers, cis-regulatory elements that control patterns of gene expression in multicellular organisms. Active enhancers produce bi-directional enhancer RNAs (eRNAs) and display CBP/p300-dependent histone acetylation. Here, we demonstrate that CBP binds directly to RNAs in vivo and in vitro. RNAs bound to CBP in vivo include a large number of eRNAs. Using steady-state...
Paper Details
Title
RNA Binding to CBP Stimulates Histone Acetylation and Transcription.
Published Date
Jan 12, 2017
Journal
Volume
168
Issue
1
Pages
135 - 149
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