Macropinocytosis of Nab-paclitaxel Drives Macrophage Activation in Pancreatic Cancer
Abstract
Pancreatic cancer is a devastating disease that is largely refractory to currently available treatment strategies. Therapeutic resistance is partially attributed to the dense stromal reaction of pancreatic ductal adenocarcinoma tumors that includes a pervasive infiltration of immunosuppressive (M2) macrophages. Nab-paclitaxel (trade name Abraxane) is a nanoparticle albumin-bound formulation of paclitaxel that, in combination with gemcitabine, is...
Paper Details
Title
Macropinocytosis of Nab-paclitaxel Drives Macrophage Activation in Pancreatic Cancer
Published Date
Feb 28, 2017
Journal
Volume
5
Issue
3
Pages
182 - 190
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