Heat shock transcription factor 1 protects against pressure overload-induced cardiac fibrosis via Smad3.

Volume: 95, Issue: 4, Pages: 445 - 460
Published: Jan 13, 2017
Abstract
Fibrotic cardiac muscle exhibits high stiffness and low compliance which are major risk factors of heart failure. Although heat shock transcription factor 1 (HSF1) was identified as an intrinsic cardioprotective factor, the role that HSF1 plays in cardiac fibrosis remains unclear. Our study aims to investigate the role of HSF1 in pressure overload-induced cardiac fibrosis and the underlying mechanism. HSF1 phosphorylation was significantly...
Paper Details
Title
Heat shock transcription factor 1 protects against pressure overload-induced cardiac fibrosis via Smad3.
Published Date
Jan 13, 2017
Volume
95
Issue
4
Pages
445 - 460
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