Design, synthesis and in vitro antitumour activity of new goniofufurone and 7- epi -goniofufurone mimics with halogen or azido groups at the C-7 position

Volume: 128, Pages: 13 - 24
Published: Mar 1, 2017
Abstract
A series of new antitumour lactones containing the [3.3.0] bicyclic furano-lactone core and the halogen or azido group at the C-7 position have been designed, synthesized, and evaluated for their in vitro antitumour activity against a panel of human tumour cell lines. Some of the analogues displayed powerful antiproliferative effects to certain human tumour cells, but all of them were devoid of any cytotoxicity towards the normal foetal lung...
Paper Details
Title
Design, synthesis and in vitro antitumour activity of new goniofufurone and 7- epi -goniofufurone mimics with halogen or azido groups at the C-7 position
Published Date
Mar 1, 2017
Volume
128
Pages
13 - 24
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