Topical application of nitrosonifedipine, a novel radical scavenger, ameliorates ischemic skin flap necrosis in a mouse model

Ischemic skin flap necrosis can occur in random pattern flaps. An excess amount of reactive oxygen species is generated and causes necrosis in the ischemic tissue. Nitrosonifedipine (NO‐NIF) has been demonstrated to possess potent radical scavenging ability. However, there has been no study on the effects of NO‐NIF on ischemic skin flap necrosis. Therefore, they evaluated the potential of NO‐NIF in ameliorating ischemic skin flap necrosis in a...