Development of chronic allergic responses by dampening Bcl6-mediated suppressor activity in memory T helper 2 cells

Significance It has been suggested that the transcriptional repressor Bcl6 suppresses T helper 2 (T H 2) immune responses underlying allergic diseases. However, the molecular role of B-cell CLL/lymphoma 6 (Bcl6) in T H 2 cells is incompletely understood in pathophysiological settings. We found that Bcl6 suppressed cytokine production in memory T H 2 cells through binding to intron 2 of the Interkeukin 4 ( Il4 ) locus using murine models....