RESEARCH PAPER Anti-angiogenic and vascular disrupting effects of C9, a new microtubule-depolymerizing agent
Published: Jan 1, 2009
Abstract
Background and purpose: The critical role of blood supply in the growth of solid tumours makes blood vessels an ideal target for anti-tumour drug discovery. The anti-angiogenic and vascular disrupting activities of C9, a newly synthesized microtubuledepolymerizing agent, were investigated with several in vitro and in vivo models. Possible mechanisms involved in its activity were also assessed. Experimental approach: Microtubule-depolymerizing...
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