Deficient retinoid-driven angiogenesis may contribute to failure of adult human lung regeneration in emphysema
Abstract
Background
Molecular pathways that regulate alveolar development and adult repair represent potential therapeutic targets for emphysema. Signalling via retinoic acid (RA), derived from vitamin A, is required for mammalian alveologenesis, and exogenous RA can induce alveolar regeneration in rodents. Little is known about RA signalling in the human lung and its potential role in lung disease.Objectives
To examine regulation of...Paper Details
Title
Deficient retinoid-driven angiogenesis may contribute to failure of adult human lung regeneration in emphysema
Published Date
Jan 13, 2017
Journal
Volume
72
Issue
6
Pages
510 - 521
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