Selective neuronal vulnerability in Parkinson disease
Abstract
Intracellular α-synuclein (α-syn)-rich protein aggregates called Lewy pathology (LP) and neuronal death are commonly found in the brains of patients with clinical Parkinson disease (cPD). It is widely believed that LP appears early in the disease and spreads in synaptically coupled brain networks, driving neuronal dysfunction and death. However, post-mortem analysis of human brains and connectome-mapping studies show that the pattern of LP in...
Paper Details
Title
Selective neuronal vulnerability in Parkinson disease
Published Date
Jan 20, 2017
Journal
Volume
18
Issue
2
Pages
101 - 113
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