Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population
Abstract
The antiretroviral nevirapine is associated with hypersensitivity reactions in 6%-10% of patients, including hepatotoxicity, maculopapular exanthema, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).To undertake a genome-wide association study (GWAS) to identify genetic predisposing factors for the different clinical phenotypes associated with nevirapine hypersensitivity.A GWAS was undertaken in a discovery cohort of 151...
Paper Details
Title
Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population
Published Date
Jan 6, 2017
Pages
dkw545 - dkw545
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