Substrates and Inhibitors of SAMHD1
Abstract
SAMHD1 hydrolyzes 2'-deoxynucleoside-5'-triphosphates (dNTPs) into 2'-deoxynucleosides and inorganic triphosphate products. In this paper, we evaluated the impact of 2' sugar moiety substitution for different nucleotides on being substrates for SAMHD1 and mechanisms of actions for the results. We found that dNTPs ((2'R)-2'-H) are only permissive in the catalytic site of SAMHD1 due to L150 exclusion of (2'R)-2'-F and (2'R)-2'-OH nucleotides....
Paper Details
Title
Substrates and Inhibitors of SAMHD1
Published Date
Jan 3, 2017
Journal
Volume
12
Issue
1
Pages
e0169052 - e0169052
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