Anti-oxidative effects of curcumin on immobilization-induced oxidative stress in rat brain, liver and kidney

Published on Mar 1, 2017in Biomedicine & Pharmacotherapy4.545
· DOI :10.1016/J.BIOPHA.2016.12.105
Saeed Samarghandian21
Estimated H-index: 21
Mohsen Azimi-Nezhad23
Estimated H-index: 23
(MUMS: Mashhad University of Medical Sciences)
+ 1 AuthorsFariborz Samini16
Estimated H-index: 16
(MUMS: Mashhad University of Medical Sciences)
Abstract Restraint stress has been indicated to induce oxidative damage in tissues. Several investigations have reported that curcumin (CUR) may have a protective effect against oxidative stress. The present study was designed to investigate the protective effects of CUR on restraint stress induced oxidative stress damage in the brain, liver and kidneys. For chronic restraint stress, rats were kept in the restrainers for 1 h every day, for 21 consecutive days. The animals received systemic administrations of CUR daily for 21 days. In order to evaluate the changes of the oxidative stress parameters following restraint stress, the levels of malondialdehyde (MDA), reduced glutathione (GSH), as well as antioxidant enzyme activities superoxide dismutase (SOD) glutathione peroxidase (GPx), glutathione reductase (GR) and catalase (CAT) were measured in the brain, liver and kidney of rats after the end of restraint stress. The restraint stress significantly increased MDA level, but decreased the level of GSH and activists of SOD, GPx, GR, and CAT the brain, liver and kidney of rats in comparison to the normal rats (P
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