NLRC5/CITA: A Key Player in Cancer Immune Surveillance

NLRC5/CITA is a key transcriptional coactivator of genes involved in the MHC class I antigen-presentation pathway, including HLA-A, -B, -C, B2M, LMP2, LMP7, and TAP1. NLRC5 is a major target of immune evasion in cancer. Genetic and epigenetic alterations such as copy number loss, DNA methylation, or somatic mutations cause the reduction of MHC class I expression or activity, leading to impaired CD8+ T cell activation. NLRC5 is a novel biomarker...