The NR4A subfamily of nuclear receptors: potential new therapeutic targets for the treatment of inflammatory diseases

Introduction: Prolonged inflammatory response contributes to the pathogenesis of chronic disease-related disturbances. Among nuclear receptors (NRs), the orphan NR4A subfamily, which includes Nur77 (NR4A1), Nurr1 (NR4A2) and NOR1 (NR4A3), has recently emerged as a therapeutic target for the treatment of inflammation.Areas covered: This review focuses on the capacity of NR4A receptors to counter-regulate the development of the inflammatory...