Autoimmune (IgG4-Related) Pancreatitis

Published on Jan 1, 2017
· DOI :10.1007/978-3-319-41349-5_6
Luca Frulloni58
Estimated H-index: 58
(University of Verona),
Antonio Amodio13
Estimated H-index: 13
(University of Verona)
Sources
Abstract
Autoimmune pancreatitis (AIP) is a peculiar form of chronic inflammatory disease of the pancreas with unique pathologic features, different from all other forms of pancreatitis. Although a possible autoimmune involvement of the pancreatic gland had been proposed since the early 1960s, the term AIP was introduced in 1995 by Yoshida et al. based on a case report and the review of the available English and Japanese literature. However only in recent years was AIP finally accepted as a distinct nosographic entity. The more relevant clinical data and the main reason for introducing the term “autoimmune pancreatitis” were the dramatic response to steroid therapy, which represents one of the cardinal diagnostic criteria, like other gastrointestinal tract diseases (e.g., autoimmune hepatitis).
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References47
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#1Arezou Khosroshahi (Emory University)H-Index: 31
#2Zachary S. Wallace (Harvard University)H-Index: 27
Last. John H. Stone (Harvard University)H-Index: 94
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A. Khosroshahi, Z. S. Wallace, J. L. Crowe, T. Akamizu, A. Azumi, M. N. Carruthers, S. T. Chari, E. Della-Torre, L. Frulloni, H. Goto, P. A. Hart, T. Kamisawa, S. Kawa, M. Kawano, M. H. Kim, Y. Kodama, K. Kubota, M. M. Lerch, M. L€ ohr, Y. Masaki, S. Matsui, T. Mimori, S. Nakamura, T. Nakazawa, H. Ohara, K. Okazaki, J. H. Ryu, T. Saeki, N. Schleinitz, A. Shimatsu, T. Shimosegawa, H. Takahashi, M. Takahira, A. Tanaka, M. Topazian, H. Umehara, G. J. Webster, T. E. Witzig, M. Yamamoto, W. Zhang, T....
445 CitationsSource
#1Riccardo Negrelli (University of Verona)H-Index: 10
#2Riccardo Manfredi (University of Verona)H-Index: 24
Last. Roberto Pozzi Mucelli (University of Verona)H-Index: 38
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Aim To evaluate the magnetic resonance (MR) imaging-MR cholangiopancreatographic (MRCP) findings of focal forms of autoimmune pancreatitis (AIP) to describe ductal involvement at diagnosis.
38 CitationsSource
#1Francesco VitaliH-Index: 2
#2Torsten HansenH-Index: 27
Last. Luca FrulloniH-Index: 58
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ObjectivesA diagnosis of benign lesions (BLs) is reported in 5% to 21% of pancreatoduodenectomies performed for neoplasms; no data for body-tail resections are available. The aims were to investigate the frequency and characterize the BLs mimicking cancer in the head and the body-tail of the pancrea
12 CitationsSource
#1Phil A. Hart (Mayo Clinic)H-Index: 29
#2Ryan J. Law (Mayo Clinic)H-Index: 2
Last. Suresh T. ChariH-Index: 103
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ObjectivesThe risk of pancreatic and extrapancreatic cancer in autoimmune pancreatitis (AIP) has not been systematically evaluated. We compared the risk of malignancy in AIP patients and matched control subjects.MethodsWe identified 116 subjects with AIP from a prospectively maintained database. Fro
56 CitationsSource
#1Phil A. Hart (Mayo Clinic)H-Index: 29
#2Terumi Kamisawa (Tokyo Metropolitan Komagome Hospital)H-Index: 77
Last. Suresh T. Chari (Mayo Clinic)H-Index: 103
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Objective Autoimmune pancreatitis (AIP) is a treatable form of chronic pancreatitis that has been increasingly recognised over the last decade. We set out to better understand the current burden of AIP at several academic institutions diagnosed using the International Consensus Diagnostic Criteria, and to describe long-term outcomes, including organs involved, treatments, relapse frequency and long-term sequelae. Design 23 institutions from 10 different countries participated in this multination...
317 CitationsSource
#1Phil A. Hart (Mayo Clinic)H-Index: 29
#2Mark Topazian (Mayo Clinic)H-Index: 65
Last. Suresh T. Chari (Mayo Clinic)H-Index: 103
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Background There is a paucity of data on long-term management of type 1 autoimmune pancreatitis (AIP), a relapsing steroid-responsive disorder. Objective We describe our experience with treatment of relapses and maintenance of remission using steroid-sparing immunomodulators (IMs) and induction of remission using rituximab (RTX). Methods We obtained details of disease relapse and treatment in 116 type 1 AIP patients from clinic visits, medical records and telephone interviews. We compared relaps...
235 CitationsSource
#1Tsukasa Ikeura (Kansai Medical University)H-Index: 19
#2Riccardo Manfredi (University of Verona)H-Index: 24
Last. Luca Frulloni (University of Verona)H-Index: 58
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27 CitationsSource
#1Masahiro Shiokawa (Kyoto University)H-Index: 13
#2Yuzo Kodama (Kyoto University)H-Index: 35
Last. Tsutomu ChibaH-Index: 105
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RESULTS: Of the 108 AIP patients, 18 cancers were found in 15 patients (13.9 % ) during the median follow-up period of 3.3 years. The SIR of cancer was 2.7 (95 % confi dence interval (CI) 1.4 - 3.9), which was stratifi ed into the fi rst year (6.1 (95 % CI 2.3 - 9.9)) and subsequent years (1.5 (95 % CI 0.3 - 2.8)) after AIP diagnosis. Relative risk of cancer among AIP patients at the time of AIP diagnosis was 4.9 (95 % CI 1.7 - 14.9). In six of eight patients whose cancer lesions could be assess...
139 CitationsSource
#1John H. Stone (Harvard University)H-Index: 94
#2Arezou Khosroshahi (Harvard University)H-Index: 31
Last. Suresh T. Chari (Mayo Clinic)H-Index: 103
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John H. Stone, Arezou Khosroshahi, Vikram Deshpande, John K. C. Chan, J. Godfrey Heathcote, Rob Aalberse, Atsushi Azumi, Donald B. Bloch, William R. Brugge, Mollie N. Carruthers, Wah Cheuk, Lynn Cornell, Carlos Fernandez-Del Castillo, Judith A. Ferry, David Forcione, Gunter Kloppel, Daniel L. Hamilos, Terumi Kamisawa, Satomi Kasashima, Shigeyuki Kawa, Mitsuhiro Kawano, Yasufumi Masaki, Kenji Notohara, Kazuichi Okazaki, Ji Kon Ryu, Takako Saeki, Dushyant Sahani, Yasuharu Sato, Thomas Smyrk, James...
447 CitationsSource
#1Atsushi Kanno (Tohoku University)H-Index: 39
#1Atsushi KannoH-Index: 18
Last. Tooru ShimosegawaH-Index: 95
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OBJECTIVES: To clarify the clinicoepidemiological features of autoimmune pancreatitis (AIP) in Japan, the nationwide survey was conducted. METHODS: Patients with AIP who had visited the selected hospitals in 2007 were surveyed. Autoimmune pancreatitis was diagnosed according to the Japanese clinical diagnostic criteria 2006. The study consisted of 2-stage surveys: the number of patients with AIP was estimated by the first questionnaire and their clinical features were assessed by the second ques...
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