Nitrogen Mustard Induces DNA Damage and Structural Changes in Mouse Skin Hair Follicles

Nitrogen mustard (NM) is a potent skin vesicant. Evidence suggests that the pilosebaceous unit in the skin is a target for NM. To assess this, we analyzed changes in hair follicles and sebaceous glands in mouse skin following NM exposure. Dorsal skin of female CD-1 mice was exposed to 77 ng NM for 6 min, and harvested 1-5 d later. Control (CTL) skin contained sebaceous glands expressing fatty acid synthase (FAS), a marker for sebum production....