P2.06-047 LRRK2-In-1 Inhibit Proliferation of Doublecortin and CaM Kinase-Like-1 (DCLK1)-Positive Lung Cancer Cells

Doublecortin and CaM kinase-like-1 (DCLK1) is a kinase that regulates microtubule polymerization in migrating neurons. DCLK1 is also suggested to be a tumor stem cell marker in colon and pancreatic cancer. The expression status of DCLK1 and its role in lung cancer remain largely unknown. LRRK2-IN-1, a potent therapeutic agent for the treatment of Parkinson’s disease, has shown to inhibit DCLK1 kinase activity. DCLK1 expression status in human...