Viminalins A-O: Diverse [3+2] hybrids of acylphloroglucinol and α-phellandrene from the fruits of Callistemon viminalis

Published on Feb 23, 2017in Tetrahedron2.233
· DOI :10.1016/J.TET.2016.12.076
Lin Wu8
Estimated H-index: 8
(CPU: China Pharmaceutical University),
Ya-Long Zhang9
Estimated H-index: 9
(CPU: China Pharmaceutical University)
+ 4 AuthorsLing-Yi Kong58
Estimated H-index: 58
(CPU: China Pharmaceutical University)
Source
Abstract
Viminalins A-O (1–15), a series of new [3+2] hybrids of acylphloroglucinols and α-phellandrene featured a 2,3-dihydrobenzofuran core were isolated from the fruits of Callistemon viminalis. Their structures were established on the basis of extensive analysis of NMR spectra, circular dichroism, and X-ray crystallography. An oxidative [3+2] cycloaddition between acylphloroglucinol and monoterpene was speculated as the key step in the biosynthetic pathway. Bioactivities screen indicated that compound 6 exhibited moderate cytotoxic activity.
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