Chitosan based nanofibers in bone tissue engineering.

Published on Nov 1, 2017in International Journal of Biological Macromolecules5.162
· DOI :10.1016/J.IJBIOMAC.2016.12.046
K. Balagangadharan10
Estimated H-index: 10
(SRM University),
S. Dhivya9
Estimated H-index: 9
(SRM University),
Nagarajan Selvamurugan59
Estimated H-index: 59
(SRM University)
Bone tissue engineering involves biomaterials, cells and regulatory factors to make biosynthetic bone grafts with efficient mineralization for regeneration of fractured or damaged bones. Out of all the techniques available for scaffold preparation, electrospinning is given priority as it can fabricate nanostructures. Also, electrospun nanofibers possess unique properties such as the high surface area to volume ratio, porosity, stability, permeability and morphological similarity to that of extra cellular matrix. Chitosan (CS) has a significant edge over other materials and as a graft material, CS can be used alone or in combination with other materials in the form of nanofibers to provide the structural and biochemical cues for acceleration of bone regeneration. Hence, this review was aimed to provide a detailed study available on CS and its composites prepared as nanofibers, and their associated properties found suitable for bone tissue engineering.
📖 Papers frequently viewed together
138 Citations
263 Citations
1,031 Citations
#1Dariush Semnani (IUT: Isfahan University of Technology)H-Index: 15
#2Elham Naghashzargar (IUT: Isfahan University of Technology)H-Index: 5
Last. Farshid Effaty (Concordia University)H-Index: 1
view all 7 authors...
ABSTRACTIn this investigation, a nanofibrous scaffold was fabricated through electrospinning of polycaprolactone (PCL) and chitosan (CS) using a novel collector to make better orientation and pore size for cell infiltration. PCL/CS nanofibers with 90-rpm collector speed and 40° angle between collector wires of the new collector have fewer diameters with better pore, size and nanofibers orientation. Mechanical properties, roughness parameters, topology, structure, hydrophilicity, and cell growing...
44 CitationsSource
#1María J Moreno-Vásquez (Universidad de Sonora)H-Index: 3
#2Emma Lucía Valenzuela-Buitimea (Universidad de Sonora)H-Index: 1
Last. A.Z. Graciano-Verdugo (Universidad de Sonora)H-Index: 10
view all 9 authors...
Abstract Chitosan was functionalized with epigallocatechin gallate (EGCG) by a free radical-induced grafting procedure, which was carried out by a redox pair (ascorbic acid/hydrogen peroxide) as the radical initiator. The successful preparation of EGCG grafted-chitosan was verified by spectroscopic (UV, FTIR and XPS) and thermal (DSC and TGA) analyses. The degree of grafting of phenolic compounds onto the chitosan was determined by the Folin-Ciocalteu procedure. Additionally, the biological acti...
54 CitationsSource
#1S. Deepthi (AIMS: Amrita Institute of Medical Sciences and Research Centre)H-Index: 14
#2M. Nivedhitha Sundaram (AIMS: Amrita Institute of Medical Sciences and Research Centre)H-Index: 7
Last. Rangasamy Jayakumar (AIMS: Amrita Institute of Medical Sciences and Research Centre)H-Index: 79
view all 4 authors...
Abstract The aim of our study was to develop a tendon construct of electrospun aligned poly ( l -lactic acid) (PLLA) nanofibers, to mimic the aligned collagen fiber bundles and layering PLLA fibers with chitosan-collagen hydrogel, to mimic the glycosaminoglycans of sheath ECM for tendon regeneration. The hydrogel coated electrospun membrane was rolled and an outer coating of alginate gel was given to prevent peritendinous adhesion. The developed constructs were characterized by SEM, FT-IR and te...
53 CitationsSource
#1Bin Li (ZJU: Zhejiang University)H-Index: 25
#2Yang Zhang (ZJU: Zhejiang University)H-Index: 7
Last. Guochang SunH-Index: 1
view all 8 authors...
This present study deals with synthesis, characterization and antibacterial activity of chitosan/TiO2 nanocomposites. Results indicated that chitosan/TiO2 nanocomposite at the ratio of 1:5 showed the strongest inhibition in growth of rice bacterial pathogen Xanthomonas oryzae pv. oryzae (Xoo). Furthermore, the antibacterial activity of chitosan/TiO2 nanocomposite against Xoo is significantly higher than that of the two individual components under both light and dark conditions. Regardless of the...
39 CitationsSource
#1Ehsan Salehi (Arak: Arak University)H-Index: 18
#2Parisa DaraeiH-Index: 19
Last. Ahmad Arabi Shamsabadi (Drexel University)H-Index: 23
view all 3 authors...
Membrane adsorbents have emerged as powerful and attractive tools for the removal of hazardous materials such as dyes and heavy metal ions, mainly in trace amounts, from water resources. Among membrane adsorbents, those prepared from or modified with chitosan biopolymer and its derivatives are cases of interest because of chitosan advantages including biocompatibility, biodegradability, nontoxicity, reactivity, film and fiber forming capacity and favorable hydrophilicity. This review is oriented...
132 CitationsSource
#1Wenqiang Tan (CAS: Chinese Academy of Sciences)H-Index: 18
#2Qing Li (CAS: Chinese Academy of Sciences)H-Index: 11
Last. Zhanyong Guo (CAS: Chinese Academy of Sciences)H-Index: 31
view all 5 authors...
In this study, a group of novel water soluble chitosan ammonium salts with halogens were successfully synthesized, including chitosan-bromoacetate (CSB), chitosan-chloroacetate (CSC), chitosan-dichloroacetate (CSDC), chitosan-trichloroacetate (CSTC), and chitosan-trifluoroacetate (CSTF), and their antifungal activities against three kinds of phytopathogens were comparatively estimated by hypha measurement in vitro, respectively. The fungicidal assessment revealed that the synthesized chitosan de...
29 CitationsSource
#1Seda Surucu (Atılım University)H-Index: 3
#2Hilal Turkoglu Sasmazel (Atılım University)H-Index: 12
Abstract This study was related to combining of synthetic Poly (e-caprolactone) (PCL) and natural chitosan polymers to develop three dimensional (3D) PCL/chitosan core-shell scaffolds for tissue engineering applications. The scaffolds were fabricated with coaxial electrospinning technique and the characterizations of the samples were done by thickness and contact angle (CA) measurements, scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-Ray Photoelectron Spectroscopy ...
41 CitationsSource
#1R. LogithKumar (SRM University)H-Index: 1
#2A. KeshavNarayan (SRM University)H-Index: 1
Last. Nagarajan Selvamurugan (SRM University)H-Index: 59
view all 6 authors...
Critical-sized bone defects treated with biomaterials offer an efficient alternative to traditional methods involving surgical reconstruction, allografts, and metal implants. Chitosan, a natural biopolymer is widely studied for bone regeneration applications owing to its tunable chemical and biological properties. However, the potential of chitosan to repair bone defects is limited due to its water insolubility, faster in vivo depolymerization, hemo-incompatibility, and weak antimicrobial proper...
263 CitationsSource
#1Wessam A. Sarhan (The: American University in Cairo)H-Index: 5
#2Hassan M.E. Azzazy (The: American University in Cairo)H-Index: 32
Last. Ibrahim M. El-SherbinyH-Index: 26
view all 3 authors...
Abstract The effect of increasing honey concentrations from 10% to 30% within the Honey (H)/polyvinyl alcohol (P)/chitosan (CS) nanofibers was investigated. Changes in the electrospun nanofiber diameters, crystallinity, thermal behavior, porosity and antibacterial activity have been assessed using SEM, XRD, DSC, TGA, mercury porosimeter and viable cell count technique. The HPCS nanofibers were cross-linked and tested for their swelling abilities and degradation behavior. The mean diameter of HPC...
26 CitationsSource
#1Bishnu Kumar Shrestha (CBNU: Chonbuk National University)H-Index: 12
#2Hamouda M. Mousa (CBNU: Chonbuk National University)H-Index: 15
Last. Cheol Sang Kim (CBNU: Chonbuk National University)H-Index: 51
view all 6 authors...
Abstract The development of biofunctional and bioactive hybrid polymeric scaffolds seek to mitigate the current challenges in the emerging field of tissue engineering. In this paper, we report the fabrication of a biomimetic and biocompatible nanofibrous scaffolds of polyamide-6,6 (PA-6,6) blended with biopolymer chitosan via one step co-electrospinning technique. Different weight percentage of chitosan 10 wt%, 15 wt%, and 20 wt% were blended with PA-6,6, respectively. The nanocomposite electros...
53 CitationsSource
Cited By96
#2Abul K. MallikH-Index: 15
Last. Mohammed M. RahmanH-Index: 66
view all 3 authors...
#1Farzad Seidi (NFU: Nanjing Forestry University)H-Index: 22
#2Mohsen Khodadadi Yazdi (UT: University of Tehran)H-Index: 8
Last. Masoud Mozafari (Lunenfeld-Tanenbaum Research Institute)H-Index: 51
view all 11 authors...
Abstract Polysaccharides are the most abundant naturally available carbohydrate polymers; composed of monosaccharide units covalently connected together. Chitosan is the most widely used polysaccharides because of its exceptional biocompatibility, mucoadhesion, and chemical versatility. However, it suffers from a few drawbacks, e.g. poor mechanical properties and antibacterial activity for biomedical applications. Blending chitosan with natural or synthetic polymers may not merely improve its ph...
#1Ana María Valencia (University of Valle)H-Index: 1
#2Carlos Valencia (University of Valle)H-Index: 8
Last. Carlos David Grande-Tovar (University of Atlántico)H-Index: 7
view all 4 authors...
Abstract Graphene oxide (GO) has recently gained attention as a scaffold reinforcing agent for tissue engineering. Biomechanical and biological properties through a synergistic effect can be strengthened when combined with other materials such as chitosan (CS). For that reason, chitosan was used for Graphene Oxide (GO) functionalization through an amide group whose formation was evident by bands around 1600 cm−1 in the FTIR analysis. Furthermore, bands located at 1348 cm−1 (D band), 1593 cm−1 (G...
#1Pejman Ghaffari-Bohlouli (UT: University of Tehran)H-Index: 4
#2Hafez Jafari (ULB: Université libre de Bruxelles)H-Index: 5
Last. Amin Shavandi (ULB: Université libre de Bruxelles)H-Index: 16
view all 7 authors...
Electrospun poly (l-lactide-co-d, l-lactide) (PLDLLA)/poly (vinyl alcohol) (PVA) nanofibers were reinforced by various contents (0-1 wt%) of phospho-calcified cellulose nanowhiskers (PCCNWs) as scaffolds in bone applications. The hydrophilicity and rate of hydrolytic degradation of PLDLLA were improved by introducing 10 wt% of PVA. PCCNWs with inherent hydrophilic properties, high aspect ratio, and large elastic modulus enhanced the hydrophilicity, accelerated the rate of degradation, and improv...
#1J. Anita Lett (SIST: Sathyabama University)H-Index: 6
#2Suresh Sagadevan (UM: University of Malaya)H-Index: 19
Last. Won-Chun Oh (Hanseo University)H-Index: 32
view all 9 authors...
Abstract New materials that mimic natural bone properties, matching functional, mechanical, and biological properties have been continuously developed to rehabilitate bone defects. Desirably, ‘tissue engineering’ has been a multidisciplinary ground that uses the principles of life sciences and engineering for the biological replacements that restore or replace the tissue function or a whole organ. Nevertheless, the bone grafting treatment has numerous restrictions, counting the major hazards of ...
#1Maurício Gonçalves da Costa Sousa (UCB: Universidade Católica de Brasília)H-Index: 5
#2Taia Maria Berto Rezende (UCB: Universidade Católica de Brasília)H-Index: 15
Last. Octavio L. Franco (UCB: Universidade Católica de Brasília)H-Index: 64
view all 3 authors...
Microbial infections are a major worldwide public health problem because a number of microorganisms can show drug resistance. Antimicrobial peptides (AMPs) are small biomolecules that present antimicrobial and immunomodulatory activities. Despite their great potential, there are still many barriers to the formulation of these molecules. In this context, nanotechnological approaches such as nanofibers are candidate drug-delivery systems for AMP formulations. These nanomaterials have a large conta...
#1Soroush Ahmadi (AUT: Amirkabir University of Technology)H-Index: 1
#2Ahmad HivechiH-Index: 7
Last. Seyedeh Sara Ashraf (IUMS: Iran University of Medical Sciences)H-Index: 1
view all 5 authors...
Abstract This study develops chitosan/gelatin nanofiber membranes with sustained release capacity to prevent infection by delivering cinnamon extract (CE) in the implanted site. The effects of the incorporation of CE content (2–6%) on the properties of the nanofibers were evaluated. Morphological studies using SEM indicated that loading the extract did not affect the average diameter of nanofiber mats, which remained around 140–170 nm. TGA and FTIR spectroscopy results confirmed successful CE lo...
2 CitationsSource
#1Seyed Yahya Rahnamaee (Sharif University of Technology)H-Index: 2
#2Reza Bagheri (Sharif University of Technology)H-Index: 27
Last. Ali Samadikuchaksaraei (IUMS: Iran University of Medical Sciences)H-Index: 30
view all 6 authors...
Abstract Designing multifunctional surfaces is key to develop advanced materials for orthopedic applications. In this study, we designed a double-layer coating, assembled onto the completely regular titania nanotubes (cRTNT) array. Benefiting from the biological and topological characteristics of chitosan nanofibers (CH) and reduced graphene oxide (RGO) through a unique assembly, the designed material features promoted osteoblast cell proliferation, prolonged antibiotic release profile, as well ...
3 CitationsSource
#1Pietro Bellet (UNIPD: University of Padua)H-Index: 1
#2Matteo Gasparotto (UNIPD: University of Padua)H-Index: 2
Last. Francesco Filippini (UNIPD: University of Padua)H-Index: 21
view all 8 authors...
Leading-edge regenerative medicine can take advantage of improved knowledge of key roles played, both in stem cell fate determination and in cell growth/differentiation, by mechano-transduction and other physicochemical stimuli from the tissue environment. This prompted advanced nanomaterials research to provide tissue engineers with next-generation scaffolds consisting of smart nanocomposites and/or hydrogels with nanofillers, where balanced combinations of specific matrices and nanomaterials c...
#1Parinaz Saadat Esbah Tabaei (UGent: Ghent University)H-Index: 5
#2Mahtab Asadian (UGent: Ghent University)H-Index: 12
Last. Nathalie De Geyter (UGent: Ghent University)H-Index: 27
view all 13 authors...
Abstract Given the complex calcified nature of the fibrous bone tissue, a combinatorial approach merging specific topographical/biochemical cues was adopted to design bone tissue-engineered scaffolds. Coral having a Ca-enriched structure was added to electrospun chitosan (CS)/polyethylene oxide (PEO) nanofibers that were subjected to plasma surface modifications using a medium pressure Ar, air or N2 dielectric barrier discharge. Plasma incorporated oxygen- and nitrogen-containing functionalities...
2 CitationsSource