Measurement and Correlation of Solubility of Amorphous Cefmetazole Sodium in Pure Solvents and Binary Solvent Mixtures

The development and design of the crystallization process strongly depend on accurate solid–liquid equilibrium data. In this paper, the solubility data of amorphous cefmetazole sodium in pure solvents (ethanol, n-propanol, i-propanol, n-butanol, n-amyl alcohol, ethyl acetate, n-butyl acetate, n-hexane, and cyclohexane) and binary solvent mixtures (methanol and ethanol) were measured by using the UV spectroscopic method and gravimetrical method,...