Abstract 61: Histone Deacetylase 9 (HDAC9) Dysregulation Precipitates High-Fat-Diet--Induced Adipose Tissue Dysfunction and Systemic Metabolic Disorders

During chronic overfeeding, adipose tissue expansion contributes to adipose inflammation, insulin resistance and obesity-related diabetes. Consequently, identifying mechanisms that promote “healthy” growth of adipose tissues could potentially improve obesity-related disease. We previously demonstrated that endogenous HDAC9 negatively regulates adipogenic differentiation in isolated preadipocytes. Here, we investigated the role of HDAC9 in...