Do CDK4/6 inhibitors have potential as targeted therapeutics for squamous cell cancers?

Published on Jan 1, 2017in Expert Opinion on Investigational Drugs5.081
· DOI :10.1080/13543784.2017.1274731
Nene N. Kalu8
Estimated H-index: 8
(University of Texas MD Anderson Cancer Center),
Faye M. Johnson37
Estimated H-index: 37
ABSTRACTIntroduction Dysregulation of cell cycle progression has an established link to neoplasia and cancer progression. Components of the cyclin D-CDK4/6-INK4-Rb pathway are frequently altered in squamous cell carcinomas (SCCs) by diverse mechanisms, including viral oncogene–induced degradation, mutation, deletion, and amplification. Activation of the CDK4/6 pathway may predict response to CDK4/6 inhibitors and provide clinical biomarkers. Recently, the CDK4/6 inhibitor palbociclib showed clinical efficacy in combination with cetuximab in HNSCC patients.Areas covered This review focuses on the current research on the use of CDK4/6 inhibitors, comprising preclinical animal studies through phase II clinical trials across all SCCs.Expert opinionCDK4/6 inhibitors have a proven clinical benefit in breast cancer, but data on SCCs are sparse. Although frequent dysregulation of the cyclin D-CDK4/6-INK4-Rb pathway in SCCs suggests that targeting CDK4/6 may hold promise for improved clinical outcomes, single-agen...
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