Effect of retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness

Rationale: Retinoid X receptors (RXRs) are members of nuclear receptor (NR) superfamily that mediates signaling by 9-cis retinoic acid, a vitamin A (retinol) derivative. RXRs play a key role as heterodimeric partners, e.g., Retinoid acid receptors (RARs), vitamin D receptors (VDRs), and peroxisome proliferator-activated receptors (PPARs). Recently, NR family is reported to associate with allergic diseases, nonetheless the role of RXRs in...