RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer

Volume: 31, Issue: 1, Pages: 94 - 109
Published: Jan 1, 2017
Abstract

Summary

Receptor-interacting protein kinase 1 (RIPK1) represents an essential signaling node in cell death and inflammation. Ablation of Ripk1 in liver parenchymal cells (LPC) did not cause a spontaneous phenotype, but led to tumor necrosis factor (TNF)-dependent hepatocyte apoptosis and liver injury without affecting inducible nuclear factor κB (NF-κB) activation. Loss of Ripk1 induced the TNF-dependent proteasomal...
Paper Details
Title
RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer
Published Date
Jan 1, 2017
Volume
31
Issue
1
Pages
94 - 109
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