Heritability of the shape of subcortical brain structures in the general population

Gennady V. Roshchupkin; Boris A. Gutman; Meike W. Vernooij; Neda Jahanshad; Nicholas G. Martin; Albert Hofman; Katie L. McMahon; Sven J. van der Lee; Cornelia M. van Duijn; Greig I. de Zubicaray; M. Arfan Ikram; Hieab H.H. Adams

doi:https://doi.org/10.1038/ncomms13738

doi.org/10.1038/ncomms13738

Heritability of the shape of subcortical brain structures in the general population

Gennady V. Roshchupkin

13

,

Boris A. Gutman

36

,

..., Hieab H.H. Adams

30

Nature Communications16.60

Volume: 7, Issue: 1

Published: Dec 15, 2016

Abstract

The volumes of subcortical brain structures are highly heritable, but genetic underpinnings of their shape remain relatively obscure. Here we determine the relative contribution of genetic factors to individual variation in the shape of seven bilateral subcortical structures: the nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen and thalamus. In 3,686 unrelated individuals aged between 45 and 98 years, brain magnetic resonance...

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Paper Details

Title

Heritability of the shape of subcortical brain structures in the general population

DOI

doi.org/10.1038/ncomms13738

Published Date

Dec 15, 2016

Journal

Nature Communications

Volume

7

Issue

1

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