Identification of metabolites of palmatine in rats after oral administration using ultra‐high‐performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry

Rationale Palmatine (PAL), a protopalmatine alkaloid, is an active constituent in a number of medicinal plants. In order to obtain a comprehensive and systematic metabolic profile of PAL, we investigated its metabolites in plasma, liver tissue, bile, urine, and feces samples after intragastrical administration to Sprague‐Dawley rats with a dose of 100 mg/kg/day. Methods In this study, a rapid and sensitive method by ultra‐high‐performance liquid...