The P2Y 2 nucleotide receptor is an inhibitor of vascular calcification
Abstract
Background and aimsMutations in the 5'-nucleotidase ecto (NT5E) gene that encodes CD73, a nucleotidase that converts AMP to adenosine, are linked to arterial calcification. However, the role of purinergic receptor signaling in the pathology of intimal calcification is not well understood. In this study, we examined whether extracellular nucleotides acting via P2Y2 receptor (P2Y2R) modulate arterial intimal calcification, a condition highly...
Paper Details
Title
The P2Y 2 nucleotide receptor is an inhibitor of vascular calcification
Published Date
Feb 1, 2017
Journal
Volume
257
Pages
38 - 46
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