Paeoniflorin ameliorates interferon-alpha-induced neuroinflammation and depressive-like behaviors in mice
Abstract
Long-term treatment with high-dose Interferon-alpha (IFN-α) has resulted in depression in 30-50% of the patients. Paeoniflorin may ameliorate the IFN-α-induced depression; however, the underlying mechanism is less studied. Here, we investigated the prophylactic antidepressant and anti-neuroinflammatory effects of paeoniflorin on the behaviors and specific emotion-related regions of the brain in mice with IFN-α-induced depression. A series of...
Paper Details
Title
Paeoniflorin ameliorates interferon-alpha-induced neuroinflammation and depressive-like behaviors in mice
Published Date
Dec 24, 2016
Journal
Volume
8
Issue
5
Pages
8264 - 8282
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