A negative feedback loop of ICER and NF-κB regulates TLR signaling in innate immune responses
Abstract
The NF-κB pathway has important roles in innate immune responses and its regulation is critical to maintain immune homeostasis. Here, we report a newly discovered feedback mechanism for the regulation of this pathway by TLR ligands in macrophages. Lipopolysaccharide (LPS) induced the expression of ICER via p38-mediated activation of CREB in macrophages. ICER, in turn, inhibited the transcriptional activity of NF-κB by direct interaction with the...
Paper Details
Title
A negative feedback loop of ICER and NF-κB regulates TLR signaling in innate immune responses
Published Date
Dec 23, 2016
Journal
Volume
24
Issue
3
Pages
492 - 499
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