Targeting DNA Repair in Cancer: Beyond PARP Inhibitors
Abstract
Germline aberrations in critical DNA-repair and DNA damage–response (DDR) genes cause cancer predisposition, whereas various tumors harbor somatic mutations causing defective DDR/DNA repair. The concept of synthetic lethality can be exploited in such malignancies, as exemplified by approval of poly(ADP-ribose) polymerase inhibitors for treating BRCA1/2-mutated ovarian cancers. Herein, we detail how cellular DDR processes engage various proteins...
Paper Details
Title
Targeting DNA Repair in Cancer: Beyond PARP Inhibitors
Published Date
Jan 1, 2017
Journal
Volume
7
Issue
1
Pages
20 - 37
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