Engaging Natural Killer T Cells as ‘Universal Helpers’ for Vaccination
Abstract
Conventional vaccine adjuvants enhance peptide-specific T-cell and B-cell responses by modifying peptide stability or uptake or by binding to pattern-recognition receptors on antigen-presenting cells (APCs). This article discusses the application of a distinct mechanism of adjuvant activity: the activation of type I, or invariant, natural killer T (iNKT) cells to drive cellular and humoral immune responses. Using a semi-invariant T-cell receptor...
Paper Details
Title
Engaging Natural Killer T Cells as ‘Universal Helpers’ for Vaccination
Published Date
Dec 22, 2016
Journal
Volume
77
Issue
1
Pages
1 - 15
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