A novel mechanism regulating human platelet activation by MMP-2–mediated PAR1 biased signaling
Abstract
Key Points Active MMP-2 enhances platelet activation by cleaving PAR1 at an extracellular site different from the thrombin cleavage site. The novel PAR1-tethered ligand exposed by MMP-2 selectively stimulates PAR1-dependent Gq and G12/13 pathway...
Paper Details
Title
A novel mechanism regulating human platelet activation by MMP-2–mediated PAR1 biased signaling
Published Date
Feb 16, 2017
Journal
Volume
129
Issue
7
Pages
883 - 895
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