Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish
Abstract
The zebrafish possesses a remarkable capacity of adult heart regeneration, but the underlying mechanisms are not well understood. Here we report that chromatin remodelling factor Brg1 is essential for adult heart regeneration. Brg1 mRNA and protein are induced during heart regeneration. Transgenic over-expression of dominant-negative Xenopus Brg1 inhibits the formation of BrdU + /Mef2C + and Tg( gata4 :EGFP) cardiomyocytes, leading to severe...
Paper Details
Title
Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish
Published Date
Dec 8, 2016
Journal
Volume
7
Issue
1
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