Original paper

Disease variants alter transcription factor levels and methylation of their binding sites

Volume: 49, Issue: 1, Pages: 131 - 138
Published: Dec 5, 2016
Abstract
Most disease-associated genetic variants are noncoding, making it challenging to design experiments to understand their functional consequences. Identification of expression quantitative trait loci (eQTLs) has been a powerful approach to infer the downstream effects of disease-associated variants, but most of these variants remain unexplained. The analysis of DNA methylation, a key component of the epigenome, offers highly complementary data on...
Paper Details
Title
Disease variants alter transcription factor levels and methylation of their binding sites
Published Date
Dec 5, 2016
Volume
49
Issue
1
Pages
131 - 138
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