Prognostic impact of CD44-positive cancer stem-like cells at the invasive front of gastric cancer.

Published on Jan 17, 2017in British Journal of Cancer7.64
路 DOI :10.1038/BJC.2016.401
Hirokazu Kodama3
Estimated H-index: 3
(Shiga University of Medical Science),
Satoshi Murata12
Estimated H-index: 12
(Shiga University of Medical Science)
+ 7 AuthorsMasaji Tani38
Estimated H-index: 38
(Shiga University of Medical Science)
Sources
Abstract
Prognostic impact of CD44-positive cancer stem-like cells at the invasive front of gastric cancer
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References34
Newest
#1Satoshi Murata (Shiga University of Medical Science)H-Index: 12
#2Hiroshi Yamamoto (Shiga University of Medical Science)H-Index: 19
Last. Masaji Tani (Shiga University of Medical Science)H-Index: 38
view all 12 authors...
Background The mechanisms underlying peritoneal metastasis (PM) after curative gastrectomy for gastric cancer (GC) are not well elucidated. This study assessed whether viable cancer cells, including cancer stemlike cells (CSCs), were present in the remnant stomach immediately before gastrointestinal (GI) tract reconstruction because these could be a source of PM after gastrectomy.
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#1Jian-Wei Xie (Fujian Medical University)H-Index: 23
#2Peng-Chen Chen (Fujian Normal University)H-Index: 4
Last. Chang-Ming Huang (Fujian Medical University)H-Index: 25
view all 12 authors...
Purpose Tumor stem cell surface marker CD44v6, a member of the CD44 protein family, is causally involved in the metastasis of cancer. Little is known about the functions of CD44v6 in gastric cancer. The aim of this study was to evaluate the prognostic value of CD44v6 and investigate its functional roles.
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#1Ying Wu (PRC: China Medical University (PRC))H-Index: 10
#2Zhi Li (PRC: China Medical University (PRC))H-Index: 17
Last. Xiaosong YuH-Index: 1
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With a meta-analysis and narrative review, we evaluated the clinical and prognostic role of all CD44 family proteins in gastric cancer (GC). Literatures published up to August 2014 were searched on PubMed. Among the 37 eligible studies (6606 patients), 34 were included in meta-analysis, and 10 were subjected to narrative review. With meta-analysis, standard CD44 (CD44s) was demonstrated to predict reduced overall survival (OS) (HR = 1.93, 95% CI: 1.58-2.34, PHR = 0.0222) and disease free surviva...
#1Naoki Mashita (Nagoya University)H-Index: 3
#2Suguru Yamada (Nagoya University)H-Index: 51
Last. Yasuhiro Kodera (Nagoya University)H-Index: 83
view all 13 authors...
Background Isoform switching of CD44 is associated with epithelial to mesenchymal transition (EMT) in several cancers; however, the clinical implications of this remain unclear for colorectal cancer (CRC). Methods We measured expression levels of E-cadherin, vimentin, CD44 standard (CD44s) and CD44 variant 9 (CD44v9) transcripts in 14 CRC cell lines and 150 CRC patients. We determined EMT and CD44 status by calculating vimentin/E-cadherin and CD44s/CD44v9 expression ratios, respectively. Associa...
Source
#1Xueyuan Cao (JLU: Jilin University)H-Index: 15
#2Donghui Cao (JLU: Jilin University)H-Index: 15
Last. Jing Jiang (JLU: Jilin University)H-Index: 18
view all 8 authors...
Background Recent studies have focused on the diagnostic and prognostic significance of CD24 and CD44 expression in human cancers. This study aimed to explore changes in CD44 and CD24 expression levels in patients with gastric cancer and to assess their prognostic values.
Source
#1Kouji Tanaka (Mie University)H-Index: 19
#2Tadanobu Shimura (Mie University)H-Index: 18
Last. Masato KusunokiH-Index: 66
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Tropomyosin-related receptor kinase B at the invasive front and tumour cell dedifferentiation in gastric cancer
Source
#1Sarah Schwitalla (Boston Children's Hospital)H-Index: 11
Every cancer cell is 鈥渄ifferent鈥濃攚ithin one and the same tumor, between different lesions originating from the same tumor, among different patients suffering from the same tumor type, and certainly between different tumor types. The complexity of tumor development, with its genetic, phenotypic and functional heterogeneity and plasticity within tumors and between primary tumors and metastases, underlies the unpredictable influences and stimuli of a tumor-associated inflammatory microenvironment, ...
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#1Katsushi Takebayashi (Shiga University of Medical Science)H-Index: 10
#2Satoshi Murata (Shiga University of Medical Science)H-Index: 12
Last. Tohru Tani (Shiga University of Medical Science)H-Index: 31
view all 13 authors...
Background Some patients who undergo curative gastrectomy with lymph node dissection (LND) for gastric cancer (GC) show subsequent peritoneal metastasis. The source of these metastatic cells remains unclear.
Source
#1Kazuhiro Sentani (Hiroshima University)H-Index: 32
#2Miho Matsuda (Hiroshima University)H-Index: 3
Last. Wataru Yasui (Hiroshima University)H-Index: 94
view all 7 authors...
Background For several types of cancer, including gastric cancer (GC), tumor cells at the invasive front are considered to have a more aggressive behavior compared with those in the more central region. The aim of the present study was to analyze the expression of MMP-7, laminin 纬2 and EGFR in a large number of GCs and to investigate how these expression patterns correlate with clinicopathologic parameters, infiltrative patterns, histology or mucin phenotype.
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#1Mohit SharmaH-Index: 8
#2Parul Sah (Manipal University)H-Index: 5
Last. Raghu Radhakrishnan (Manipal University)H-Index: 15
view all 4 authors...
Treatment planning for oral squamous cell carcinoma (OSCC) is based on the clinical TNM (Tumor, Node and Metastasis) classification. This system operates on the assumption that small tumours without clinical spread have a better prognosis than larger tumours with metastases. However, it is a well-known fact that some tumours with the same clinical staging show different growth patterns and clinical behaviour. This makes the prognosis for patients with OSCC difficult to predict on the basis of cl...
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Cited By38
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#1Shumei Song (University of Texas MD Anderson Cancer Center)H-Index: 23
#2Yan Xu (PRC: China Medical University (PRC))H-Index: 9
Last. Yibo Fan (University of Texas MD Anderson Cancer Center)H-Index: 1
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Background null Gastric adenocarcinoma with peritoneal carcinomatosis (PC) is therapy resistant and leads to poor survival. To study PC in depth, there is an urgent need to develop representative PC-derived cell lines and metastatic models to study molecular mechanisms of PC and for preclinical screening of new therapies. null Methods null PC cell lines were developed from patient-derived PC cells. The tumorigenicity and metastatic potential were investigated by subcutaneously (PDXs) and orthoto...
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#1Tomoko Jogo (Kyushu University)H-Index: 6
#2Eiji Oki (Kyushu University)H-Index: 59
Last. Masaki Mori (Kyushu University)H-Index: 133
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BACKGROUND CD44 variant 9 (CD44v9) has been reported to suppress reactive oxygen spices (ROS) in association with antioxidant factors such as glutathione (GSH) and glutathione peroxidase 2 (GPx2), resulting in promoted tumor growth. METHODS CD44v9 and GPx2 expression were investigated by immunohistochemistry in resected specimens from 193 gastric cancer (GC) patients without preoperative chemotherapy and in pretreatment biopsy specimens from 29 GC patients with preoperative chemotherapy. We anal...
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#1Zohreh Yaghobi (Tabriz University of Medical Sciences)H-Index: 1
#2Ali Akbar Movassaghpour (Tabriz University of Medical Sciences)H-Index: 16
Last. Behzad Baradaran (Tabriz University of Medical Sciences)H-Index: 50
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CD44 is a cell surface adhesion molecule, which is overexpressed on cancer stem cells. The interaction of CD44 with hyaluronan is responsible for tumor development, metastasis, and expression of the chemoresistant phenotype. The overexpression of CD44 impedes the cytotoxic effect of chemotherapy medications in various cancers. Therefore, the high expression of CD44 is associated with a poor prognosis in affected patients. This high expression of CD44 in various cancers has provided an ample oppo...
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#1Lornella Seeneevassen (University of Bordeaux)H-Index: 5
#2Emilie Bess猫de (University of Bordeaux)H-Index: 14
Last. Christine Varon (University of Bordeaux)H-Index: 23
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Gastric cancer's bad incidence, prognosis, cellular and molecular heterogeneity amongst others make this disease a major health issue worldwide. Understanding this affliction is a priority for proper patients' management and for the development of efficient therapeutical strategies. This review gives an overview of major scientific advances, made during the past 5-years, to improve the comprehension of gastric adenocarcinoma. A focus was made on the different actors of gastric carcinogenesis, in...
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#1Diba Borzabadi Farahani (Razi University)H-Index: 2
#2Hassan Akrami (Shiraz University of Medical Sciences)H-Index: 12
Last. Mohammad Reza Fattahi (Shiraz University of Medical Sciences)H-Index: 20
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Numerous researches have extensively studied factors such as microRNAs that lead to cancer. Thus, the current study's purpose is to investigate the biological consequences of hsa-miR-451b inhibition on the properties and functions of gastric cancer stem-like cells. First, gastric cancer stem-like cells were transfected by hsa-miR-451b inhibitor then we used real-time RT-PCR to evaluate its effect on the expression of hsa-miR-451b and two of its direct target genes, Stemness markers such as KLF4,...
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#1Mahdieh Razmi (IUMS: Iran University of Medical Sciences)H-Index: 1
#2Roya Ghods (IUMS: Iran University of Medical Sciences)H-Index: 11
Last. Zahra Madjd (IUMS: Iran University of Medical Sciences)H-Index: 26
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BACKGROUND Gastric cancer (GC) is considered one of the most lethal malignancies worldwide, which is accompanied by a poor prognosis. Although reports regarding the importance of cancer stem cell (CSC) markers in gastric cancer progression have rapidly developed over the last few decades, their clinicopathological and prognostic values in gastric cancer still remain inconclusive. Therefore, the current meta-analysis aimed to quantitatively re-evaluate the association of CSC markers expression, o...
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#1Peiwen Chen (University of Texas MD Anderson Cancer Center)H-Index: 22
#2Wen Hao Hsu (University of Texas MD Anderson Cancer Center)H-Index: 2
Last. Ronald A. DePinho (University of Texas MD Anderson Cancer Center)H-Index: 172
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Cancer stem cells (CSCs) are self-renewing cells that facilitate tumor initiation, promote metastasis, and enhance cancer therapy resistance. Transcriptomic analyses across many cancer types have revealed a prominent association between stemness and immune signatures, potentially implying a biological interaction between such hallmark features of cancer. Emerging experimental evidence has substantiated the influence of CSCs on immune cells, including tumor-associated macrophages, myeloid-derived...
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#1Theodoros Rampias (Academy of Athens)H-Index: 13
Mutational processes constantly shape the cancer genome and defects in DNA repair pathways of tumor cells facilitate the accumulation of genomic alterations [...]
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#1Shamshul Ansari (Chitwan Medical College)H-Index: 16
#2Yoshio Yamaoka (Oita University)H-Index: 91
Helicobacter pylori causes persistent infection in the gastric epithelium of more than half of the world's population, leading to the development of severe complications such as peptic ulcer diseases, gastric cancer, and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Several virulence factors, including cytotoxin-associated gene A (CagA), which is translocated into the gastric epithelium via the type 4 secretory system (T4SS), have been indicated to play a vital role in disease devel...
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#1Lia Walcher (Fraunhofer Society)H-Index: 2
#2Ann-Kathrin Kistenmacher (Fraunhofer Society)H-Index: 2
Last. Uta Kossatz-Boehlert (Fraunhofer Society)H-Index: 3
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The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest over the last decades. In particular, the analysis of biomarkers in cancer patients within the pre- and post-therapeutic period is required to identify several types of cells, which carry a risk for a disease progression and subsequent post-therapeutic relapse. Cancer stem cells (CSCs) are a subpopulation of tumor cells that can drive tumor initiation and can cause relapses. At the time point of tumor initia...
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