Cardiac oxidative stress in diabetes: Mechanisms and therapeutic potential
Abstract
Macrovascular complications of diabetes, including diabetic cardiovascular disease (CVD), occur through a number of hyperglycaemia-induced mechanisms that include generation of oxidative stress, accumulation of advanced glycation end-products (AGE) and activation of protein kinase C (PKC). Cardiac oxidative stress is associated with increased cardiac fibrosis and hypertrophy, and reduced cardiac performance and contractility, leading to severe...
Paper Details
Title
Cardiac oxidative stress in diabetes: Mechanisms and therapeutic potential
Published Date
Apr 1, 2017
Journal
Volume
172
Pages
50 - 62
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