Clinical Translation of Tumor Acidosis Measurements with AcidoCEST MRI
Abstract
We optimized acido-chemical exchange saturation transfer (acidoCEST) magnetic resonance imaging (MRI), a method that measures extracellular pH (pHe), and translated this method to the radiology clinic to evaluate tumor acidosis. A CEST-FISP MRI protocol was used to image a flank SKOV3 tumor model. Bloch fitting modified to include the direct estimation of pH was developed to generate parametric maps of tumor pHe in the SKOV3 tumor model, a...
Paper Details
Title
Clinical Translation of Tumor Acidosis Measurements with AcidoCEST MRI
Published Date
Aug 1, 2017
Volume
19
Issue
4
Pages
617 - 625
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