Icariin ameliorates IgA nephropathy by inhibition of nuclear factor kappa b/Nlrp3 pathway

Immunoglobulin A nephropathy (Ig AN ) is the most frequent form of glomerulonephritis, which is characterized by glomerular proliferation and renal inflammation. Icariin is a flavonoid from the Chinese herb Epimedium, and its anti‐inflammatory effect has been reported. This study aimed to investigate the effects of icariin on the renal damage in Ig AN rats and the mechanisms behind these effects. Ig AN model was established in Sprague–Dawley...