Functional variants in the sucrase–isomaltase gene associate with increased risk of irritable bowel syndrome
Abstract
IBS is a common gut disorder of uncertain pathogenesis. Among other factors, genetics and certain foods are proposed to contribute. Congenital sucrase-isomaltase deficiency (CSID) is a rare genetic form of disaccharide malabsorption characterised by diarrhoea, abdominal pain and bloating, which are features common to IBS. We tested sucrase-isomaltase (SI) gene variants for their potential relevance in IBS.We sequenced SI exons in seven familial...
Paper Details
Title
Functional variants in the sucrase–isomaltase gene associate with increased risk of irritable bowel syndrome
Published Date
Nov 21, 2016
Journal
Volume
67
Issue
2
Pages
263 - 270
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