Vasculogenic mimicry in small cell lung cancer.
Abstract
Small cell lung cancer (SCLC) is characterized by prevalent circulating tumour cells (CTCs), early metastasis and poor prognosis. We show that SCLC patients (37/38) have rare CTC subpopulations co-expressing vascular endothelial-cadherin (VE-cadherin) and cytokeratins consistent with vasculogenic mimicry (VM), a process whereby tumour cells form 'endothelial-like' vessels. Single-cell genomic analysis reveals characteristic SCLC genomic changes...
Paper Details
Title
Vasculogenic mimicry in small cell lung cancer.
Published Date
Nov 9, 2016
Journal
Volume
7
Issue
1
Pages
13322 - 13322
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Notes
History