Management of Macular Edema in Vitreo-Maculopathies

Published on Jan 1, 2017
路 DOI :10.1007/978-3-319-39766-5_6
Matin Khoshnevis5
Estimated H-index: 5
(TU: Temple University),
Jerry Sebag33
Estimated H-index: 33
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Abstract
Anomalous PVD is the fundamental cause of vitreo-maculopathies with vitreo-macular traction and macular pucker, both associated with macular edema.
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#1Justin NguyenH-Index: 6
#2Kenneth M.P. YeeH-Index: 12
Last. Alfredo A. Sadun (UCLA: University of California, Los Angeles)H-Index: 75
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Purpose To measure the effects of macular pucker (MP) on macular structure and quantify function by measuring visual acuity (VA), contrast sensitivity (CS), and distortions. The effects of surgery were quantitatively evaluated using these measures. Design Prospective, comparative case series. Participants Fifty-three patients with unilateral MP and normal fellow eyes: 24 operated MP subjects, 17 unoperated controls, and 12 reproducibility subjects. Methods Posterior vitreous detachment was diagn...
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#1Radhika Krishnan (Moorfields Eye Hospital)H-Index: 1
#2Rashi AroraH-Index: 3
Last. Srinivas GoverdhanH-Index: 2
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Purpose: To evaluate the effect of vitreomacular traction (VMT) on visual acuity outcomes and central retinal thickness (CRT) measurements after intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy for treatment of exudative age-related macular degeneration (AMD). Methods: In this retrospective series, the authors evaluate the clinical records and optical coherence tomography of 34 eyes of 32 patients, with VMT confirmed on optical coherence tomography at baseline, to assess ...
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#1Roger L. NovackH-Index: 9
#2Giovanni StaurenghiH-Index: 44
Last. Michael J. TolentinoH-Index: 32
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Purpose The evaluation of the safety and preliminary efficacy of 125 渭g ocriplasmin intravitreal injection in patients with focal vitreomacular adhesion (VMA) and exudative age-related macular degeneration (AMD). Design Randomized, sham-injection controlled, double-masked, multicenter, phase II trial. Participants A total of 100 patients with VMA and wet AMD were randomized 3:1 to receive 125 渭g ocriplasmin intravitreal injection or sham injection. Methods Study treatment was administered in the...
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#1Matin Khoshnevis (UCI: University of California, Irvine)H-Index: 5
#2Jerry SebagH-Index: 33
With increased knowledge about the origins and pathophysiology of vitreo-retinal disorders鈥攁nd, in particular, the central role of anomalous posterior vitreous detachment in vitreo-maculopathies鈥攁 paradigm shift from surgery to pharmacotherapy is taking place with the development of pharmacologic vitreolysis. The first approved agent for pharmacologic vitreolysis therapy is ocriplasmin, a truncated form of the nonspecific serine protease plasmin. Twelve studies comprise the current ocriplasmin c...
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#2John A. WellsH-Index: 22
#3Adam R. GlassmanH-Index: 5
Last. Jennifer K. Sun (Harvard University)H-Index: 42
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Purpose: To provide 2-year results comparing antievascular endothelial growth factor (VEGF) agents for center-involved diabetic macular edema (DME) using a standardized follow-up and retreatment regimen. Design: Randomized clinical trial. Participants: Six hundred sixty participants with visual acuity (VA) impairment from DME. Methods: Randomization to 2.0-mg aflibercept, 1.25-mg repackaged (compounded) bevacizumab, or 0.3mg ranibizumab intravitreous injections performed up to monthly using a pr...
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PURPOSE. Macular pucker (MP) and macular hole (MH) are vitreomaculopathies treated by vitrectomy and membrane peel. The complication of postoperative central scotoma can be associated with significant reduction in visual acuity (VA). We seek to determine whether retinal nerve fiber layer (RNFL) disruption is the pathophysiologic basis of this defect. Mitigating clinical circumstances also were sought. METHODS. Eleven eyes from 10 pseudophakic patients who had undergone vitrectomy with peeling fo...
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#1Sebastian M. Waldstein (Medical University of Vienna)H-Index: 27
#2Markus Ritter (Medical University of Vienna)H-Index: 15
Last. Ursula Schmidt-Erfurth (Medical University of Vienna)H-Index: 92
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Purpose To investigate the influence of vitreomacular adhesion on the efficacy of pro re nata (PRN) ranibizumab monotherapy and verteporfin photodynamic therapy (PDT) combination therapy for neovascular age-related macular degeneration. Design Post hoc analysis of prospective randomized 12-month multicenter clinical trial data. Methods patient population: Total of 255 treatment-naive patients with subfoveal choroidal neovascularization. observation procedure: Assessment of the vitreomacular inte...
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#1Tasanee Braithwaite (Moorfields Eye Hospital)H-Index: 11
#2Afshan A. Nanji (Bascom Palmer Eye Institute)H-Index: 14
Last. Paul B. Greenberg (Brown University)H-Index: 21
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Background Central retinal vein occlusion (CRVO) is a common retinal vascular disorder in which macular edema (ME) may develop, with a consequent reduction in visual acuity. The visual prognosis in CRVO-ME is poor in a substantial proportion of patients, especially those with the ischemic subtype, and until recently there has been no treatment of proven benefit. Macular grid laser treatment is ineffective, and whilst a few recent randomized controlled trials (RCTs) suggest short-term gains in vi...
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#2Susanne BinderH-Index: 36
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Retinal vascular occlusions are traditionally considered major causes of ocular morbidity due to their drastic impact on central visual function. Modern ophthalmology has introduced an array of new therapeutic modalities that are being tested through clinical trials with promising results. Therapies such as anti-vascular endothelial growth factors, VEGF receptor binding agents, and steroid pharmacotherapy are rapidly evolving to replace traditional conservative treatment and laser therapy. While...
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ABSTRACT Macromolecules comprise only 2% of vitreous, yet account for its gel state, transparency, and physiologic function(s) within the eye. Myopia and aging alter collagen and hyaluronan association causing concurrent gel liquefaction and fibrous degeneration. The resulting vitreous opacities and collapse of the vitreous body during posterior vitreous detachment are the most common causes for the visual phenomenon of vitreous floaters. Previously considered innocuous, the vitreous opacities t...
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