A molecular dynamics study of the binary complexes of APP, JIP1, and the cargo binding domain of KLC

Volume: 85, Issue: 2, Pages: 221 - 234
Published: Nov 28, 2016
Abstract
Mutations in the amyloid precursor protein (APP) are responsible for the formation of amyloid-β peptides. These peptides play a role in Alzheimer's and other dementia-related diseases. The cargo binding domain of the kinesin-1 light chain motor protein (KLC1) may be responsible for transporting APP either directly or via interaction with C-jun N-terminal kinase-interacting protein 1 (JIP1). However, to date there has been no direct experimental...
Paper Details
Title
A molecular dynamics study of the binary complexes of APP, JIP1, and the cargo binding domain of KLC
Published Date
Nov 28, 2016
Journal
Volume
85
Issue
2
Pages
221 - 234
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