Classification of Tandem Mass Spectra for Identification of N- and O-linked Glycopeptides
Abstract
Analysis of intact glycopeptides by mass spectrometry is essential to determining the microheterogeneity of protein glycosylation. Higher-energy collisional dissociation (HCD) fragmentation of glycopeptides generates mono- or disaccharide ions called oxonium ions that carry information about the structure of the fragmented glycans. Here, we investigated the link between glycan structures and the intensity of oxonium ions in the spectra of...
Paper Details
Title
Classification of Tandem Mass Spectra for Identification of N- and O-linked Glycopeptides
Published Date
Nov 21, 2016
Journal
Volume
6
Issue
1
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