Effect of oxidative stress and rhinovirus infection on mitochondrial/endoplasmic reticular function in human primary bronchial epithelial cells

Asthma is characterised by chronic airway inflammation and increased susceptibility to virus infections, such as Rhinovirus (RV), consequently the airway epithelium is exposed to high levels of oxidative stress. The Mitochondria play a central role in cellular metabolism and the immune response to virus infections. While mitochondrial dysfunction has been described in many chronic inflammatory diseases, little is known about its role in airway...