Principal component analysis based unsupervised feature extraction applied to publicly available gene expression profiles provides new insights into the mechanisms of action of histone deacetylase inhibitors

Publicly available gene expression profiles of the hippocampus measured during the successful administration of the histone deacetylase inhibitor, CI-994, to assist the extinction of mice contextual fear conditioning were re-analyzed using the recently proposed principal component analysis based unsupervised feature extraction. We identified 30 genes associated with differential gene expression in the hippocampus of mice treated with the HDAC...