Kidney disease

Epidemiology

Systemic lupus erythematosus

Nephritis

Intensive care medicine

Disease

Pathogenesis

Internal medicine

Renal function

Immunology

Medicine

Lupus nephritis

Clinical Journal of the American Society of Nephrology

SLE is a chronic inflammatory disease that affects the kidneys in about 50% of patients. Lupus nephritis is a major risk factor for overall morbidity and mortality in SLE, and despite potent anti-inflammatory and immunosuppressive therapies still ends in CKD or ESRD for too many patients. This review highlights recent updates in our understanding of disease epidemiology, genetics, pathogenesis, and treatment in an effort to establish a framework for lupus nephritis management that is patient-specific and oriented toward maintaining long-term kidney function in patients with lupus.

Update on Lupus Nephritis