Original paper

Amyloid fibrils from the N-terminal prion protein fragment are infectious

Volume: 113, Issue: 48, Pages: 13851 - 13856
Published: Nov 14, 2016
Abstract
Significance Prion diseases are a group of transmissible neurodegenerative disorders. The protein-only hypothesis asserts that transmission of these diseases does not require nucleic acids and that a misfolded, aggregated form of the prion protein represents a self-perpetuating infectious agent. Even though this model is supported by a large body of experimental data, there is a dispute regarding the role of specific cofactors in prion...
Paper Details
Title
Amyloid fibrils from the N-terminal prion protein fragment are infectious
Published Date
Nov 14, 2016
Volume
113
Issue
48
Pages
13851 - 13856
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