Original paper

The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization

Volume: 7, Issue: 1
Published: Nov 24, 2016
Abstract
Vascular permeability and neovascularization are implicated in many diseases including retinopathies and diabetic wound healing. Robo4 is an endothelial-specific transmembrane receptor that stabilizes the vasculature, as shown in Robo4 −/− mice that develop hyperpermeability, but how Robo4 signals remained unclear. Here we show that Robo4 deletion enhances permeability and revascularization in oxygen-induced retinopathy (OIR) and accelerates...
Paper Details
Title
The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization
Published Date
Nov 24, 2016
Volume
7
Issue
1
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